| MiCBT Research – selected studies

Group Mindfulness-Integrated Cognitive Behavior Therapy (MiCBT) Reduces Depression and Anxiety and Improves Flourishing in a Transdiagnostic Primary Care Sample Compared to Treatment-as-Usual: A Randomized Controlled Trial

Sarah E. B. Francis 1, Frances Shawyer1, Bruno Cayoun2, Joanne Enticott1,3 and Graham N. Meadows1,4,5

1 Southern Synergy, Department of Psychiatry, School of Clinical Sciences at Monash Health, Monash University, Melbourne, VIC, Australia
2 Mindfulness-Integrated Cognitive Behavior Therapy Institute, Hobart, TAS, Australia
3 Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia
4 Mental Health Program, Monash Health, Melbourne, VIC, Australia
5 Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, Australia


Objectives: This study investigated the effectiveness of a group-based 8-week intervention, Mindfulness-integrated Cognitive Behavior Therapy (MiCBT), to decrease psychological distress and increase wellbeing in a heterogeneous population in primary health care. MiCBT focuses on the importance of interoception and its interaction with cognition in emotional experience. These interactions are represented in the co-emergence model of reinforcement, in which non-reactivity (equanimity) to interoceptive signals facilitates adaptive behavior.

Methods: Participants (n = 125, aged 20–72) were randomized to two groups (MiCBT), and treatment-as-usual (TAU). Outcomes were assessed at pre-, mid-, and post-intervention and at 6-month follow-up. The primary outcome was psychological distress, measured by the Depression, Anxiety and Stress Scale (DASS-21). Secondary outcome measures were the Kessler Psychological Distress Scale-10 (K10), Satisfaction with Life Scale (SWLS), and Flourishing Scale (FS). Mediator or process measures of interoceptive awareness, metacognitive awareness (decentering), equanimity, and social functioning were included to investigate putative mediators.

Results: The MiCBT intervention significantly reduced DASS-21 scores at mid and post-treatment and the gains were maintained at 6-month follow-up (p < 0.0001, d = 0.38). Flourishing scores also showed significant improvement post-treatment and at 6-month follow-up (d = 0.24, p < 0.0001). All measures selected showed a similar pattern of positive change, with the exception of the SWLS, which failed to reach significance. Mediation analysis suggested equanimity to be the most influential mediator of the primary outcome.

The results support the effectiveness of MiCBT in creating rapid and sustainable reduction of psychological distress and improvement in flourishing in a primary mental health care setting with heterogenous groups. These promising results support the scaled-up implementation of this intervention.

Frontiers in Psychiatry, 31 May 2022

Group Mindfulness-Integrated Cognitive Behavior Therapy (MiCBT) Reduces Depression and Anxiety and Improves Flourishing in a Transdiagnostic Primary Care Sample Compared to Treatment-as-Usual: A Randomized Controlled Trial

June 10, 2022

Validation and Factor Structure of the Mindfulness‑Based Self Efficacy Scale‑Revised

February 7, 2022

Managing type 2 diabetes and depression with Mindfulness-integrated Cognitive Behavior Therapy (MiCBT)

February 2, 2022

The Effectiveness of Mindfulness-integrated Cognitive Behavioral Therapy (MiCBT), Meta-Cognitive Therapy (MCT), Acceptance and Commitment Therapy (ACT), and Cognitive Behavioral Therapy (CBT) on Obsessive-compulsive disorder (OCD)

October 15, 2021

Combined identification of lncRNA NONHSAG004550 and NONHSAT125420 as a potential diagnostic biomarker of perinatal depression

June 15, 2021

Co-emergence Reinforcement and Its Relevance to Interoceptive Desensitization in Mindfulness and Therapies Aiming at Transdiagnostic Efficacy

December 29, 2020

Development and Validation of the Equanimity Scale-16

October 3, 2020

Effectiveness of Mindfulness-integrated Cognitive Behavioral Therapy on the emotional states and quality of life of patients with multiple sclerosis: A clinical trial study

May 13, 2020

Effectiveness of mindfulness-integrated cognitive behavior therapy on anxiety, depression and hope in multiple sclerosis patients: a randomized clinical trial

April 17, 2020

Study protocol for a randomized control trial to investigate the effectiveness of an 8-week mindfulness-integrated cognitive behavior therapy (MiCBT) transdiagnostic group intervention for primary care patients

February 9, 2020
Scroll to Top
Forgot Password
Enter your email address or username and we’ll send you instructions to reset your password.